2nd International Conference on Non-invasive Cardiac Imaging, Nuclear Cardiology & Echocardiography
Amsterdam, Netherlands
Ahmed A. Battah
Cairo University, Egypt
Title: Apelin, nitric oxide and vascular affection in adolescent type 1 diabetic patients
Biography
Biography: Ahmed A. Battah
Abstract
Objective : We are aiming to evaluate apelin and nitric oxide (NO) in type 1 diabetic patients and its relation to vascular affection.
Patients and methods: The study included 62 type 1 diabetic patients and 30 healthy volunteers of the same age and sex. Blood samples were taken for assessment of apelin, NO, glycosylated hemoglobin, and lipid profile. Urine samples were taken for assessment of albumin/creatinine ratio flow mediated dilatation (FMD) via ultrasound was done .
Results: The mean age of diabetic patients were 16.3 ± 1.5 yrs ( 14.0 – 19.0 yrs), and mean duration of diabetes were 9.4 ± 2.9 yrs ( 5.0 – 16.5 yrs). FMD and FMD/ nitrate mediated dilatation (NMD) ratio were significantly lower in diabetics. Nitric oxide was significantly lower , while apelin and albumin/ creatinine ratio were significantly higher than controls. No significant correlation was found between apelin, NO, FMD, albumin / creatinie ratio or BMI.
Conclusion: Diabetic patients had endothelial dysfunction and elevation of apelin, but they does not related to each other. BMI had no relation to apelin which indicate that obesity had no role to apelin. Further large study is recommended to detect the relationship of apelin with vascular affection by assesseing large numer of diabetics with and without complication.
